Auburn vs. Vanderbilt
Vanderbilt has endured 25 consecutive losing seasons, but the Commodores are looking to go 5-0 for the first time since 1943, and are trying to earn their first bowl appearance since the 1982 Hall of Fame Classic. They find themselves in sole possession of first place in the SEC Eastern Division. Auburn needs a win on Saturday to have a realistic shot of capturing the SEC Western Division title. The Tigers did derail the Commodores’ early season success last year with a 35-7 blowout win at Auburn. Coverage will begin at 6 PM EST Saturday on ESPN.

Florida State vs. Miami
Both teams seem to be on the right track in restoring their reputations as conference contenders despite inconsistent early season performances. This will be the second straight meeting in which neither school is ranked in the polls, and it will be the first time that Miami won’t be hosting the game in the Orange Bowl. Miami’s old home had been a house of horrors for Florida State coach Bobby Bowden, as he was 5-9 against the Canes at the Orange Bowl. Regional coverage begins at 12:30 PM EST Saturday on ABC.

Ohio State vs. Wisconsin
The Terrelle Pryor Show continues this week on the road. He has shown the skills that made him the # 1 recruit in the nation by proving he can run and pass in back-to-back home victories over Troy and Minnesota. Now comes the real test – a game at Wisconsin’s raucous and rowdy Camp Randall Stadium. The talented Badgers are no doubt angry, as they’re coming off a 27-21 loss at Michigan in which they blew a 19-0 halftime lead. Regional coverage begins Saturday at 8 PM EST on ABC. Click here for the official Ohio State vs. Wisconsin smack thread.

Chicago Cubs vs. Los Angeles Dodgers
Do you believe in curses? If you live in Chicago and root for the Cubs, yes you do. Cubby fans get excited every April, and are heartbroken by October. They have endured eight straight playoff losses, including five in a row under Lou Piniella. The Cubs will have to play better baseball in Los Angeles to bring the series back to Chicago. But history doesn’t bode well for Cub fans, as Piniella is 3-10 in playoff games against Joe Torre, and the 2001 New York Yankees are the only team to come back from a 0-2 deficit in a divisional series. Guess who managed that team….Joe Torre. Saturday’s game 3 coverage will begin 10 PM EST and if necessary Sunday’s game 4 at 4 PM EST on TBS.

Kansas vs. South Florida
Seeking a repeat of their 2007 season, Coach Mark Mangino leads the 13th-ranked Jayhawks into Miami’s Raymond James Stadium on Friday night, when they face-off against #19 South Florida. This will be the second meeting between the two schools, the other was in 2006, a 13-7 Jayhawk victory in Lawrence. (click here for Anthony Stalter’s game preview)

Ohio State vs. USC
This game is being billed as “The Collision at the Coliseum,” but the Jaws of Life might be needed to save the Buckeyes if they do not bring their “A” game to Los Angeles. The key to this matchup is for OSU’s offensive line to get physical with Southern Cal’s defensive front. If they do not win the battle at the line of scrimmage, it will not matter who is running the football for Ohio State (RB Chris “Beanie” Wells, ankle, is a game-time decision). Road wins against the Trojans are a scarce commodity in the Pete Carroll era, as they hold a 39-3 mark at the Coliseum. This contest will played on Saturday night in front of a nationally-televised audience on ABC at 8:00 PM EST.

Wisconsin vs. Fresno State
The Badgers will travel to Central Valley, California to play in the most important game in Bulldog football history. Fresno State dominated Rutgers in their season opener, but they will need a victory Saturday night to keep their hopes of a BCS bowl berth alive. Wisconsin just needs a win to stay in the national title hunt. Tune in Saturday night at 10:30 PM EST on ESPN2 for this pivotal non-conference game.

Milwaukee Brewers vs. Philadelphia Phillies
The Brewers are trying to avoid another late-season collapse after coughing up an 8 ½ game lead in the NL Central last season. The Phillies will try to use this series as a springboard in getting back to the post-season. This is a key four-game series for both teams, with the Brewers three games ahead of the Phillies in the NL Wild Card race after losing the series opener last night 6-3 in Philadelphia.

San Diego Chargers vs. Denver Broncos
Too many injuries for the Chargers to overcome this week, with Shawne Merriman on the mend until 2009 and now LaDainan Tomlinson and Antonio Gates each nursing injured big toes. (But both are expected to play on Sunday.) The Broncos offense appeared to be in mid-season form in their opener on Monday night.. Were they that good or were the Raiders that dreadful? That question will not be answered for at least another month, but a victory in this game could go a long way in establishing the Broncos as an AFC contender. Check your local CBS affiliate to see if they are televising this game at 4:00 PM ET.