Ohio State vs. Michigan State
Ohio State cannot afford to look past the Spartans this week in anticipation of their game against Penn State on October 25th. The Buckeyes will be back in the national title chase if they win their next two games, and who would have predicted that after their loss to Southern Cal? Michigan State has the ultimate workhorse Javon Ringer, an Ohio native that leads the nation in rushing with 1,112 yards and scored 14 touchdowns. He has quietly become a viable Heisman Trophy candidate. Regional coverage will begin Saturday at 3:30 PM ET on the ABC/ESPN family of networks.

Missouri vs. Texas
Texas is No. 1 in the polls during the regular season for the first time since 1984. But coach Mack Brown can remind his players that the 1984 squad went on to lose four of their last five games to finish 7-4-1 and out of the national title hunt. History is working against Missouri, as the Tigers are 0-10 lifetime vs. No.1 teams, and are winless in Austin since 1896. That’s right…1896. This game pits Missouri quarterback Chase Daniel trying to re-establish himself in the Heisman race against Longhorns quarterback Colt McCoy, who some believe is the Heisman front-runner. National coverage will begin Saturday at 8 PM ET on ABC.

Boston Red Sox vs. Tampa Bay Rays
Baseball fans have been lulled to sleep this post-season by uninspiring play, with no series going one game beyond the required number. And with nine outs remaining, Tampa’s bullpen fell apart and blew a seven-run lead in an 8-7 loss to the Boston Red Sox in Game Five. We now have a series to watch. The never give-up Red Sox could force a Game Seven if struggling post-season ace Josh Beckett can muster a victory against James Shields in Tampa Bay. Game Six will begin Saturday at 8 PM ET and if necessary Game Seven will begin Sunday at 8 PM ET. Both games can be seen on TBS.

Kansas vs. South Florida
Seeking a repeat of their 2007 season, Coach Mark Mangino leads the 13th-ranked Jayhawks into Miami’s Raymond James Stadium on Friday night, when they face-off against #19 South Florida. This will be the second meeting between the two schools, the other was in 2006, a 13-7 Jayhawk victory in Lawrence. (click here for Anthony Stalter’s game preview)

Ohio State vs. USC
This game is being billed as “The Collision at the Coliseum,” but the Jaws of Life might be needed to save the Buckeyes if they do not bring their “A” game to Los Angeles. The key to this matchup is for OSU’s offensive line to get physical with Southern Cal’s defensive front. If they do not win the battle at the line of scrimmage, it will not matter who is running the football for Ohio State (RB Chris “Beanie” Wells, ankle, is a game-time decision). Road wins against the Trojans are a scarce commodity in the Pete Carroll era, as they hold a 39-3 mark at the Coliseum. This contest will played on Saturday night in front of a nationally-televised audience on ABC at 8:00 PM EST.

Wisconsin vs. Fresno State
The Badgers will travel to Central Valley, California to play in the most important game in Bulldog football history. Fresno State dominated Rutgers in their season opener, but they will need a victory Saturday night to keep their hopes of a BCS bowl berth alive. Wisconsin just needs a win to stay in the national title hunt. Tune in Saturday night at 10:30 PM EST on ESPN2 for this pivotal non-conference game.

Milwaukee Brewers vs. Philadelphia Phillies
The Brewers are trying to avoid another late-season collapse after coughing up an 8 ½ game lead in the NL Central last season. The Phillies will try to use this series as a springboard in getting back to the post-season. This is a key four-game series for both teams, with the Brewers three games ahead of the Phillies in the NL Wild Card race after losing the series opener last night 6-3 in Philadelphia.

San Diego Chargers vs. Denver Broncos
Too many injuries for the Chargers to overcome this week, with Shawne Merriman on the mend until 2009 and now LaDainan Tomlinson and Antonio Gates each nursing injured big toes. (But both are expected to play on Sunday.) The Broncos offense appeared to be in mid-season form in their opener on Monday night.. Were they that good or were the Raiders that dreadful? That question will not be answered for at least another month, but a victory in this game could go a long way in establishing the Broncos as an AFC contender. Check your local CBS affiliate to see if they are televising this game at 4:00 PM ET.

Labor Day has traditionally been the last weekend to wear white, but it is now time to don your school colors for the start of the college football season.

– Al Groh wishes he still had Chris Long anchoring his defensive front this weekend. His Cavaliers could still give USC some trouble if they can exploit the young, inexperienced Trojan offensive line. University of Virginia will host Southern Cal on Saturday in front of a nationally televised audience on ABC beginning at 3:30 p.m. EST.

– All eyes will be on The Big House on the University of Michigan campus, as the Rich Rodriquez era begins in Maize and Blue. This game might depend on whether or not Utah’s inexperienced front seven can control Michigan’s playmakers at the line of scrimmage. The Wolverines will host the Runnin’ Utes late Saturday afternoon at 3:00 p.m. EST on ESPNU.

– A In a classic border war, Illinois travels to the Edward Jones Dome in St. Louis to play host Missouri. Heisman Trophy candidate QB Chase Daniels will show off his throwing skills in the primetime matchup, and he will have a lot of firepower to throw to on the Tigers side of the ball. But do not underestimate the Missouri defense, which has 10 starters returning. The Fighting Illini will miss the leadership of Rashard Mendenhall this season, as they rely on freshman WR Regis Benn to lead their offense. Check local listings on which ESPN/ABC family of channels will be broadcasting this game on Saturday evening at 8:00 p.m. EST.