Time to check out the big games, top matchups and potential upsets as college football heads into Week 6.

Top 25 vs. Top 25:
No. 14 Ohio State at No. 18 Wisconsin, 8:00 PM ET
This was supposed to be a matchup of the best two teams in the Big Ten, but after the Badgers were embarrassed last week in Ann Arbor, this game has lost a lot of it’s luster. Despite Michigan turning the ball over five times and spotting them a 19-0 lead, Wisconsin fell apart in the second half as the Wolverines pulled off a 27-25 upset. For the Buckeyes, they seem to be playing with a chip on their shoulder after losing to USC a few weeks back, especially freshman QB Terrelle Pryor, who is out to use this game as proof that he can play on a big stage. It’ll be interesting to see how the dazzlingly Pryor does in his first road start of his young collegiate career; OSU has not won back-to-back games vs. Wisconsin since 1995/1996. Oddsmakers have established the Buckeyes as 1.5-point favorites.

No. 13 Auburn at No. 19 Vanderbilt, 6:00 PM ET
Vandy is off to a surprising 4-0 start this season, but their record is a bit deceiving. The Commodores rank last in the SEC in total offense and defense, and have been out gained in 3 of their 4 games this season. But they sit undefeated largely due to their plus-nine turnover margin, which leads the nation. They’ll get their first real test of the season against Auburn, who crushed the Commodores 45-7 in their last trip to Vanderbilt Stadium in 2003. The Tigers also handed Vandy a 35-7 beat-down last year and are trying to build some momentum off of last week’s 14-12 win against Tennessee. Still, this is the first time Vanderbilt has been ranked since 1984, so the home crowd will noty doubt be psyched. And it’s not like Tommy Tummerville’s team has been that dominant this season. (See the Tigers’ 3-2 victory over Mississippi State as proof.) Vandy is a 4.5-point home underdog.

No. 23 Oregon at No. 9 USC, 8:00 PM ET
The Trojans try to bounce back from their humiliating 27-21 loss to Oregon State last week – a defeat that dropped them from the top spot in the rankings. When these two teams met last year in Eugene, the Ducks used an electrifying home crowd to knock off the Trojans 24-17 in USC QB Mark Sanchez’s first start. It would be wise for Oregon to borrow the blueprint left by the Beavers and attack the middle of the Trojans’ beat up defense on the ground. Head coach Pete Carroll is dying to use this game to show USC can still compete for a national title this season and will try to flatten the Ducks, but Oregon’s defense is good enough to keep them in the game. The Trojans are currently 17-point favorites.

Upset Watch: No. 4 Missouri at Nebraska, 9:00 PM ET
It’s hard to fathom that the Tigers would stumble this week in Lincoln coming off a bye week and with so much on the line. But Heisman Trophy candidate Chase Daniel has yet to see a decent defense outside of Illinois in the opener. And even though MIZZOU hammered the Huskers last year, Nebraska’s defense is a lot better than the unit that surrendered 41 points to Daniel and the Tigers last year. Missouri has better talent and the better overall team, but one thing to keep in mind is that the home team in this series has won the last six in a row. MIZZOU is an 11-point favorite.

Other notable games:
No. 1 Oklahoma at Baylor, 12:30 PM ET Saturday
The Sooners play their first game since being anointed the top ranked team in the nation. They get a decent opponent in the Bears, who have been a dramatically improved team with scrappy freshman Robert Griffin under center this year.

Kentucky at No. 2 Alabama, 3:30 PM ET Saturday
After crushing the Bulldogs in Athens last week, Nick Saban’s Tide can’t fall victims to the upset themselves this week against the unranked Wildcats.

No. 5 Texas at Colorado, 7:00 PM ET Saturday
Longhorns’ QB Colt McCoy will look to continue his bid to become this year’s Heisman Trophy winner, but he’ll face a decent Colorado team who is 3-0 at home this year.