Bills vs. Saints, 1:00PM ET
Even with Jimmy Graham likely to miss the game with a foot injury, the Saints offense should score plenty against a Buffalo defense that allows 25.4 points per game. Conversely, the Bills haven’t had issues reaching pay dirt themselves, as they’re the only team in the NFL that has scored at least 20 points per contest. The over is 5-1 in Buffalo’s last six games overall and 6-0 in New Orleans’ last six games following a bye week.
FREE PICK: Over 48

49ers vs. Jaguars, 1:00PM ET
The Jaguars have been a disaster this season and the Niners are rounding into the same form that made them NFC title champs a season ago. That said, San Francisco hasn’t been home in two weeks after its players traveled to Tennessee last Sunday and then hopped a flight directly after that to head to London for today’s game. With all of that traveling, plus an inflated spread due to Jacksonville’s overall ineffectiveness, the Jags should cover today over seas. The Niners are 2-5 against the spread in their last seven games versus a team with a losing record and are due to have a letdown.
FREE PICK: Jaguars +17

Redskins vs. Broncos, 4:25PM ET
The over has cashed every week in Denver games and there’s no reason to believe the combined score won’t sail over again with Washington in town today. Over the past three weeks RGIII has looked more like the dynamic player he was a year ago as he’s beginning to have more success as a runner. He’s still highly inaccurate but the Redskins racked up 45 points last Sunday on the Bears and should have success today versus a Broncos defense that has struggled. The over is 4-1 in the last five meetings between these two teams and while the total is set high for this contest, both teams should reach the 30s.
FREE PICK: Over 57.5

Falcons vs. Cardinals, 4:25PM ET
Atlanta is highly banged up but will get running back Steven Jackson back this week after he missed over a month with a hamstring injury. The Falcons proved a week ago versus Tampa Bay that they can still move the ball effectively thanks to Matt Ryan’s ability to find weaknesses in the defense and get the ball out of his hand quickly. On the flip side, Bruce Arians is having a difficult time with his offense. The line has had massive issues protecting quarterback Carson Palmer, who is turning the ball over on a game-by-game basis. Atlanta’s pass rush has been non-exsistent this year but it should drum up enough pressure to keep Arizona’s offense at bay for another week. The Cardinals are just 2-10-1 against the spread in their last 13 games in October while the Falcons are 5-1 ATS in their last six games in Week 8.
FREE PICK: Falcons +1