Time to check out the big games, top matchups and potential upsets as college football heads into Week 7.

Top 25 vs. Top 25

No. 5 Texas at No. 1 Oklahoma, 12:00 PM ET ABC
Boy the schedule makers really screwed ABC by showing this game at Noon didn’t they? People on the west coast will have to get up at 9:00 AM to see the best game of the week. Ouch. The Sooners get a huge boost to their defense with the expected return of DT DeMarcus Granger and redshirt freshman Frank Alexander. They should help generate a pass rush, which will be imperative in stopping Heisman candidate Colt McCoy. Offensively for OU, the switch to the no-huddle has been a tremendous success for QB Sam Bradford, who seemingly has a leg-up on McCoy in the Heisman race. This game will come down to which secondary can rise to the challenge and which team can establish a running game against their opponents’ stingy front seven. At least on the onset, the Sooners have the edge in both categories.

No. 17 Oklahoma State at No. 3 Missouri, 8:00 PM ET ESPN2
This is going to be a shootout, which only favors QB Chase Daniel and the host Tigers. Missouri has scored in 19 of 20 quarters this year and have now gone 49 straight possessions with no three-and-outs. That’s a remarkable feat to say the least. But the Cowboys bring plenty of offense to the table themselves, scoring 56 points per game in their last four outings. Although MIZZOU doesn’t provide a huge challenge defensively, it must be noted that OK State has yet to face a tough defense on the road this year. The Tigers are 14-point favorites and that bodes well considering they’re 12-3 in their last 15 games as the favored team.

No. 4 LSU at No. 11 Florida, 8:00 PM ET CBS
Things got interesting on Tuesday when Tigers’ DL Ricky Jean-Francois stated that if he and his linemates got the opportunity, that they would take Florida QB Tim Tebow out of the game. Considering the Gators will try to use this game as a springboard to get back into the national championship hunt, Jean-Francois’s comments only fuel the fire. LSU has a new set of cornerbacks this year who have suffered communication breakdowns in previous games. Expect Tebow and speedy wideout Percy Harvin to try and torch the inexperienced Tigers’ secondary. Even though they have the edge in the plls, it’ll be tough sledding for LSU this Saturday in “The Swamp,” especially considering Gators’ head coach Urban Meyer is 22-2 lifetime in Gainesville.

Upset Watch

No. 13 Vanderbilt at Mississippi State, 2:30 PM ET
The Commodores have the better overall team, talent and coaching, but if the 2008 College Football Season has taught us anything so far, it’s to expect the unexpected. This is a dangerous game for Vandy considering its coming off an emotional home win over Auburn and now have to go on the road to face an inferior Bulldog squad. Where the Commodores are currently ranked is roughly where East Carolina (college football’s previous Cinderella story) was a couple weeks ago when they were upset by NC State on the road. Granted, NC State is arguably a better team than Mississippi State, but the SEC doesn’t produce cupcake programs. Beware the upset.

Other notable games:
No. 6 Penn State at Wisconsin, 8:00 PM ET ESPN
The Badgers have dropped their first two Big Ten games of the season while the high-powered Nittany Lions are out to prove that they’re the best team in the conference.

Tennessee at No. 10 Georgia, 3:30 PM ET CBS
The Vols are off to a 0-2 start in the SEC, but they gave Auburn a run for their money a few weeks ago. This is always a great matchup and nothing beats a SEC game “Between the Hedges.”

Notre Dame at No. 22 North Carolina, 3:30 PM ET
Some believe the Irish are back after starting the season 4-1 and they’ll get the opportunity to prove it facing the ranked Tar Heels on the road.