Sunday’s Best: Panthers (4-1) at Buccaneers (3-2), 1:00 PM ET FOX
This isn’t the sexiest matchup on the Week 6 schedule, but it’s a battle for first place in the NFC South. Carolina is coming off a 34-0 rout of the Chiefs, a game in which they held Larry Johnson to only two yards rushing, while Tampa dropped a close one in Denver. The Panthers can thank a healthy Jake Delhomme and a stingy run defense for their hot start this season. With Delhomme back under center and a nice 1-2 punch of DeAngelo Williams and rookie Jonathan Stewart in the backfield, the Panthers’ offense has been incredibly balanced this season and therefore, hard to stop. And Carolina’s front seven has kept opponents from averaging over 100 yards on the ground. The Bucs will go back to Jeff Garcia at quarterback with Brian Griese nursing an injured arm. It’ll be interesting to see if the Panthers take away Tampa’s 8th-best rushing attack, because the last time the Bucs couldn’t run the ball was against the Bears – a game in which Griese attempted 67 passes. Will Garcia have to do the same this week?

Upset Watch: Cowboys (4-1) at Cardinals (3-2), 4:15 PM ET FOX
I’m going right back to the well. In my primer last week, I warned to watch out for the Cards upsetting the previously unbeaten Bills. I’ll do the same this week as the Cowboys roll into the desert after almost blowing a 17-point lead to the Bengals last Sunday. Dallas has more talent than any other team in the NFC, but they’ve proven to be as fragile as T.O.’s emotions. Arizona flat out plays a different brand of football at home and could have wideout Anquan Boldin back this week, although it’s doubtful. Even without Boldin, the Cards have more than enough weapons to score on a Dallas defense that is giving up close to 23 points a game. The key obviously will be whether or not Arizona can stop the Cowboys’ high-powered offense. Dallas is racking up over 400 yards and 30 points a game and the Cards are just two games removed from surrendering 56 points to the Jets. Even if ‘Zona can’t pull off the upset, I would expect one wild shootout.

Intriguing Matchup: Patriots (3-1) at Chargers (2-3) 8:15 PM ET NBC
Remember when New England mocked Shawne Merriman’s “Lights Out” dance after a playoff win in San Diego a couple of years ago and hurt LaDainian Tomlinson’s feelings? The Pats return to the scene of the crime and no team plays with a bigger chip on their shoulder (and for really no reason) than the Chargers. Even though they won in convincing fashion against the 49ers last week, this is clearly a different Patriots team without Tom Brady. (What a statement, I know). It’ll be interesting to see if Matt Cassel can have a coming out party this weekend, because no team in the entire NFL is playing worse against the pass right now than San Diego.

Other Notable Games:
Bears (3-2) at Falcons (3-2), 1:00 PM ET FOX
The last time rookie QB Matt Ryan faced the Tampa 2 defense he had his worst outing as a pro, throwing two interceptions in a loss to the Bucs in Week 2. He’ll get a chance for redemption this week against Chicago, a team that has typically owned Atlanta in the past.

Jaguars (2-3) at Broncos (4-1), 4:15 PM ET FOX
Big Ben and the Steelers lit up Jacksonville’s defense last week. Will Jay Cutler and the Broncos’ offense do the same on Sunday?

Ravens (2-2) at Colts (2-2), 1:00 PM ET CBS
Peyton Manning vs. Ray Lewis is always fun to watch.