Rex Ryan is frustrated, and you can hardly blame him. He watched rookie Geno Smith toss three interceptions in the last preseason game, and then he watched Mark Sanchez hurt his shoulder in preseason garbage time.

The Buffalo Bills have their own issues, with Kevin Kolb suffering another concussion that could keep him out for the season or possibly threaten his career. Meanwhile top draft pick EJ Manuel may not be ready for the opener against the Patriots as he heels from a knee injury. If he can’t play, then the Bills will have to start Washington State undrafted rookie Jeff Tuel.

The Raiders look like a complete mess, and they’re so desperate that they’re considering having Terrelle Pryor start week one. Pryor hasn’t looked terrible but he still a very raw passer. Matt Flynn has a sore elbow, which doesn’t help a guy who has had another mediocre preseason.

The NFL is very hard to predict, and often you’ll see teams suddenly turn things on in week one. But you have to be skeptical with these three teams, and when we look at the odds for week one, you have to consider picking their opponents, even considering the larger spreads.

Buffalo is currently a ten-point underdog at home against the Patriots. Considering the problems at the quarterback position and that cornerback Stephon Gilmore has been lost with a broken left wrist, things look pretty bad for the Bills. The question is whether you want to lay ten points with the Bills playing at home.

The Raiders are on the road against Andrew Luck and the Colts as a 9-point underdog, and this one seems like a gift. I suspect the line might move even more in Indy’s favor, as Andrew Luck looks like he’s getting even better as he enters his second year. I love the Colts here.

The Jets are a home underdog as Tampa Bay is giving them three points. I would wait to see what happens at quarterback here. If Sanchez is healthy I would avoid it, but if Geno Smith has to start, then Tampa might be an interesting bet.