Indianapolis Colts’ safety Bob Sanders will miss the next four to six weeks with a high ankle sprain.

“He’ll be back, that’s for sure,” Polian said. “At this point we’re not sure of the severity, but I would say four-to-six (weeks) is probably the reasonable assumption.”

Sanders, the NFL’s reigning Defensive Player of the Year, injured his right ankle during the second half of Sunday’s 18-15 victory at Minnesota.

Polian indicated Sanders also might undergo arthroscopic “cleanup” surgery on one of his knees while he is recovering from the ankle injury. That would enable Sanders to avoid offseason surgery, “which is always a good thing,” Polian said.

Terrible news for the Colts. They were already having issues stopping the run and now they lose their best overall defender. The Jaguars’ running game could potentially get back on track this Sunday in Indy.