MINNEAPOLIS - SEPTEMBER 26: Quarterback Brett Favre  of the Minnesota Vikings drops back to pass against the Detroit Lions during the second half at Hubert H. Humphrey Metrodome on September 26, 2010 in Minneapolis, Minnesota. The Vikings defeated the Lions 24-10. (Photo by Jeff Gross/Getty Images)

Chiefs (3-0) at Colts (2-2), 1:00PM ET
If somebody had said before the season that the Colts wouldn’t be the undefeated team in this matchup, I would have called them a liar and punched them square in the mouth (hey, that’s not nice). The Chiefs have a golden opportunity to prove that they’re for real and have had two weeks to prepare for this game. Of course, this is an Indianapolis team that is still stewing from their last-second loss to the Jaguars last Sunday. If KC can get their running game moving with Thomas Jones and Jamaal Charles, they’ll have a shot to pull off the upset.
Current Point Spread: Colts –8

Packers (3-1) at Redskins (2-2), 1:00PM ET
Thanks to their victory over the Eagles last Sunday, the Redskins are keeping pace in the NFC East. Today it was discovered that Clinton Portis would miss the next 4-6 weeks due to a groin injury, which means Ryan Torain will now be the featured back in D.C. Speaking of backs, the Packers either never considered a trade or failed to pull the trigger in time to acquire Marshawn Lynch from the Bills. Their running game has struggled thus far and the offense continues to be reliant on Aaron Rodgers. If Washington can drum up a decent pass rush, another upset is within its reach.
Current Point Spread: Redskins +2.5

Giants (2-2) at Texans (3-1), 1:00PM ET
The pass rush that helped the Giants beat the Patriots in the Super Bowl four years ago showed up last Sunday night against the Bears. The G-Men will need that type of pressure again this week if they’re going to take down a Texans team that should get Andre Johnson back from injury. Of course, Houston has already proven that it has the capability of being balanced offensively thanks to running back Arian Foster. But can the Texans’ poor pass defense slow Eli Manning this week?
Current Point Spread: Texans –3

Vikings (1-2) at Jets (3-1), 8:30PM ET, Monday
ESPN couldn’t have asked for a better matchup on Monday night. Brett Favre will make his not-so-triumphant return to the Big Apple after retiring his way out of New York following the 2008 season. He’ll have a new weapon at his disposal in Randy Moss, who was acquired from the Patriots on Wednesday. Moss will arrive just in time to face Darrelle Revis, who held him to only two catches a couple of weeks ago when the Jets beat his former team in New York. Of course, Moss also scored twice and will no doubt get plenty of looks from his new quarterback.
Current Point Spread: Jets -4

2010 NFL Week 5 Point Spreads & Over/Under Totals

411 Denver Broncos +7 (39.5)
412 Baltimore Ravens –7 (39.5)

413 Jacksonville Jaguars +1 (41)
414 Buffalo Bills –1 (41)

415 Kansas City Chiefs +9 (44)
416 Indianapolis Colts –9 (44)

417 St. Louis Rams +3 (43)
418 Detroit Lions –3 (43)

419 Atlanta Falcons –3 (41)
420 Cleveland Browns +3 (41)

421 Tampa Bay Buccaneers +7 (38)
422 Cincinnati Bengals –7 (38)

423 Chicago Bears -1.5 (35)
424 Carolina Panthers +1.5 (35)

427 New York Giants +3 (47.5)
428 Houston Texans -3 (47.5)

429 New Orleans Saints –6.5 (46.5)
430 Arizona Cardinals +6.5 (46.5)

431 San Diego Chargers –5.5 (44.5)
432 Oakland Raiders +5.5 (44.5)

433 Tennessee Titans +6.5 (41.5)
434 Dallas Cowboys –6.5 (41.5)

435 Philadelphia Eagles +3.5 (38)
436 San Francisco 49ers –3.5 (38)

437 Minnesota Vikings +4.5 (37.5)
438 New York Jets –4.5 (37.5)

Make some cash with your questionable habits! SBR’s Beat the Prick Handicapping contest kicks off on Sept. 7, with up to $10,000 up for grabs in weekly prizes. Do you know football? Enter now!