Time to check out the big games, top matchups and potential upsets as college football heads into Week 3.

Top 25 Action:
No. 5 Ohio State (2-0) at No. 1 USC (1-0), Saturday 8:00 PM ET ABC
OSU head coach Jim Tressel said Tuesday that Heisman candidate Beanie Wells will play Saturday in Southern Cal. The Buckeyes are going to need all the offensive firepower they can get against one of the best front sevens in the nation. USC quarterback Mark Sanchez shredded Virginia for over 300 yards and three touchdowns in Week 1, but OSU’s defense is loaded with experienced talent. This is one of the most anticipated college football games of the year and should be a tight contest, although oddsmakers have made the Trojans 10.5-point favorites. (Check out our offical Ohio State-USC smack talk thread as well.)

No. 13 Kansas (2-0) at No. 19 South Florida (2-0), Friday 8:00 PM ET ESPN2
This is a tremendous matchup to kick off the Week 3 schedule as Kansas and its high-powered offense take on South Florida, which has the No. 1 ranked defense in college football. In their two wins, the Jayhawks averaged over 450 yards a game, but they go up against a Bulls’ defense Friday night that has only allowed an average of 161.5 yards per game. Oddsmakers have listed South Florida as a 3-point home favorite.

No. 10 Wisconsin (2-0) at No. 21 Fresno State (1-0), 10:30 PM ET ESPN2
Marshall rolled out to a 14-0 lead on the Badgers last week before Wisconsin eventually settled down and hammered the Thundering Heard 51-14 to improve to 2-0 on the year. Fresno State dismantled Rutgers 24-7 in New Jersey in Week 1 and should be well rested coming off a bye last week. One thing to keep an eye on is the health status of Wisconsin TE Travis Beckum, who missed the Badgers’ first two games this year with a bad hamstring. Beckum is highly regarded as one of the top tight end prospect in college football and is expected to play this weekend.

No. 2 Georgia (2-0) at South Carolina (1-1), Saturday 3:30 PM ET CBS
Before being upset by Vanderbilt last week, the Game Cocks were supposed to be Georgia’s first real test of the 2008 season. One has to assume that South Carolina is going to come out fired up after being bounced from the top 25 following their loss to the Commodores. The Bulldogs absolutely hammered Central Michigan last week, but can’t take anything for granted this Saturday playing a pissed off Steve Spurrier squad. SC is a 7.5-point home underdog.

Upset Watch:
UCLA (1-0) at No. 18 BYU (2-0)
Washington gave BYU all it could handle in Week 2 before the Cougars eventually eked out a 28-27 win. And the last time we saw the Bruins, they were upsetting Tennessee in the first week of the season. While this wouldn’t be a huge upset, it would be the second time in two chances that UCLA knocks off a ranked opponent. And with Fresno State, Oregon, California, ASU and USC on their schedule, the Bruins will have plenty of opportunities to make some noise and possibly become one of the best surprises of the season. BYU is currently an 8-point favorite.

Other notable games:
No. 14 East Carolina at Tulane – Saturday, 3:00 PM ET
No. 3 Oklahoma at Washington – Saturday, 7:45 PM ET
Arkansas at No. 8 Texas – Saturday, 3:30 PM ET

Time to check out the big games, top matchups and potential upsets as college football heads into Week 2.

Top 25 Action:
None. Nobody in the top 25 plays each other this weekend, which must have the television networks really, really excited.

Keep your eye on:
Ohio (0-1) at No. 3 Ohio State (1-0)
The Buckeyes should have no problem with instate rival Ohio this weekend, but it’ll be interesting to see if head coach Jim Tressel plays injured running back and Heisman hopeful Chris Wells. With a trip to Southern Cal on the docket, there’s no reason to play Wells this week against a cupcake like Ohio. (Although I’ll be the first to note that the MAC deserves more attention than what it gets. See the “Upset Watch” section for proof.) A running back-by-committee of David Herron, Maurice Wells and Brandon Saine should be more than enough for OSU to roll the Bobcats, so there should be no reason for “Beanie” to even dress.

Upset Watch:
No. 8 West Virginia (1-0) at East Carolina (0-1)
While it’s true that I wouldn’t even have mentioned this game had it not been for the Pirates knocking off VA Tech last week, East Carolina has proven that it can hang with top programs. ECU will be looking for its third straight win over a ranked opponent, although West Virginia has won seven straight over the Pirates coming into this contest. Oddsmakers clearly feel that ECU can hang with the Mountaineers given that WVU is only an 8-point favorite.

Central Michigan (1-0) at No. 2 Georgia (1-0)
Yes, outside of the MAC last year the Chippewas got smacked by Kansas (52-7) and Purdue (45-22). But as Bowling Green proved by beating PITT last week, the MAC has some talented teams and CMU is currently the class of the conference. They have a Hesiman candidate at quarterback in Dan LeFevour and a playmaker at running back in Ontario Sneed. There’s no doubt Georgia has better and deeper talent and it’s tough for any team to win between the hedges (let alone a MAC team), but could UGA overlook little ol’ CMU with a trip to South Carolina on the schedule next week? Obviously oddsmakers don’t think so as they’ve made the Dawgs a 24-point favorite.

Other notable games:
Miami (FL) at No. 5 Florida – Saturday, Sept 6, 8:00pm ET
No. 15 BYU at Washington – Saturday, Sept 6, 3:00pm ET
Mississippi at No. 20 Wake Forest – Saturday, Sept 6, 3:300pm ET

The line is old, tired and clichéd by I’m going to use it anyway: Football is back!

This is the opening week of college football with action kicking off Thursday, August 25 and running through Labor Day, Monday, September 1. Below is our Week 1 College Football Primer.

Top 25 Action:
No. 20 Illinois at No. 6 Missouri – Saturday, August 30, 8:30pm ET
Ron Zook and the Illini try to build on their 2007 success with a trip to Missouri to take on the No. 6 Tigers. Quarterback Chase Daniel looks to start his Heisman Trophy campaign off with a bang as he’ll face an Illinois defense that ranked 83rd in the nation against the pass last season. Even though this looks like a mismatch in favor of Missouri, clearly oddsmakers feel that the Illini can keep the game close considering the Tigers opened up as 8.5-point favorites.

No. 24 Alabama at No. 9 Clemson – Saturday, August 30, 8:00pm ET
The Tigers are considered the favorites to win the ACC this season, but Tommy Bowden’s crew has found a way to underachieve in the past. Clemson arguably has the best senior quarterback in the country Cullen Harper and the ACC’s best backfield tandem in James Davis and C.J. Spiller. For Alabama, Nick Saban’s team is expected to be improved this year and should give Clemson a game this weekend.

Keep your eye on:
Hawaii at No. 5 Florida – Saturday, August 30, 12:30pm ET
Hawaii lost their all-time leading passer Colt Brennan to the NFL and head coach June Jones to SMU, but the Warriors are still expected to light up the scoreboard. The Gators are clearly the better team, led by 2007 Heisman winner Tim Tebow, but Hawaii is no cupcake opponent. Think there might be some points scored in this game? Oddsmakers have established the over/under total at a whopping 71 points.

Upset Watch:
Appalachian State at No. 7 LSU – Saturday, August 30, 5:00pm ET
The Mountaineers couldn’t do it again could they? LSU is solid in the trenches and should be able to overpower tiny App State, but the same was said last year when the Mountaineers rolled into Ann Arbor and knocked off Michigan. With the explosive Armanti Edwards at quarterback, anything is possible.

Other noteable games:
No. 3 USC at Virginia – Saturday, August 30, 3:30pm ET
Washington at No. 21 Oregon – Saturday, August 30, 10:00pm ET
No. 18 Tennessee at UCLA – Monday, September 1, 8:00pm ET