Patriots @ Steelers, 4:15PM ET
This is an intriguing matchup not only because of the two teams but also due to the individual matches within the game. The Patriots arguably have the most efficient passing attack in the league, but they’ve struggled defending the pass for much of the season. Thanks to Ben Roethlisberger and the big-play ability of Pittsburgh’s receivers, the Steelers could strike for a long score at any point. I think this one will live up to the hype and with a whole slew of garbage matchups on the Week 8 schedule, I hope it does.

Cowboys @ Eagles, 8:20PM ET
It’s time to see how many of the Eagles’ problems Andy Reid was able to iron out over the bye week. Philadelphia looked great against Washington the week before its bye, but Dallas will provide a more difficult challenge than the Redskins did. DeMarco Murray is coming off a breakout game and the Eagles haven’t been able to stop the run all season. If Murray can get going again, the Cowboys have a chance to potentially put the nail in the coffin of their bitter rivals.

Lions @ Broncos, 4:05PM ET
The Lions have more pressing issues to worry about than whether or not Ndamukong Suh is a dirty player. Matthew Stafford (ankle) is hobbled, Jahvid Best (concussion) is out for another week and the defense can’t stop the run. The Broncos might not be the better overall team in this matchup but Tim Tebow has breathed new life into Denver and will be fired up to play at home. This will not be an easy road trip this weekend for the Lions.

Vikings @ Panthers, 1:00PM ET
Rookie quarterbacks will be on display this Sunday in Carolina when the Panthers host the Vikings. Outside of the two interceptions he threw to Charles Woodson in the third quarter last week, the Vikings had to be pleased with Christian Ponder’s first professional start. If Minnesota wants to give Ponder an opportunity to notch his first win, then the Vikes better get Adrian Peterson revved up. Carolina’s run defense has been bad all year and it would be wise to keep Cam Newton on the bench considering how bad Minnesota’s pass defense is.

Chargers @ Chiefs, 8:30PM ET Monday
This matchup certainly got more interesting over the past few weeks. After starting the year 0-3 the Chiefs have rattled off three-straight and who can forget the beating they gave the Chargers on Monday night last season? Of course, they won’t have Jamaal Charles this time around but Jackie Battle is starting to come on as KC’s leading rusher. The Chargers’ offense was blanked in the second half last Sunday against the Jets, leading to speculation about whether or not Philip Rivers may be hurt. If he’s not, then it’s time for him to step up on Monday night in what has turned out to be a pretty big divisional game.

Jaguars @ Texans, 1:00PM ET
Blaine Gabbert has received most of the attention this year in Jacksonville, but it’s been the Jaguar defense that has stolen the show. They absolutely dominated the Ravens on Monday night and thanks to strong play out of linebackers Daryl Smith and Paul Posluszny, Jacksonville ranks sixth in yards allowed this season. The Jags’ defense will certainly be tested this weekend, especially if Andre Johnson returns from the hamstring injury that has held him out for nearly a month.

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Sunday’s Best: Giants (5-1) at Steelers (5-1), 4:15 PM ET
Does a matchup get more physical than this? The biggest news surrounding this game on the injury front is that Willie Parker is expected to return to the Steelers’ backfield this week after missing last Sunday’s win over the Bengals after aggravating his knee injury. He faces a tough front seven of the Giants, who bounced back last Sunday against San Francisco after being embarrassed on Monday night football two weeks ago in Cleveland. New York’s defense complied six sacks, forced four fumbles, intercepted two passes and held the 49ers to 2 of 10 on third downs. One thing to note is that the Steelers were manhandled by an Eagles team early in the season that runs a similar defensive scheme as the Giants do. Expect the G-Men to game plan against the run while blitzing Ben Roethlisberger early and often. Pittsburgh’s banged up offensive line is ranked 28th in sacks allowed, which doesn’t paint a pretty picture for Big Ben this weekend. Still, expect a Steeler defense pumped for the opportunity to stifle Eli Manning, Brandon Jacobs and the rest of New York’s explosive offense.

Upset Watch: Falcons (4-2) at Eagles (3-3), 1:00 PM ET
Bragging alert: I’ve called the last four upset-watches and five of the first seven this season. And if Martin Gramatica wasn’t awful, I would have nailed the Saints over the Broncos in Week 3 as well. I’m going out on a major limb this week in calling a Falcons upset over the Eagles. Not only is Philly a 9-point favorite, but the Eagles are also 9-0 under Andy Reid coming off the bye. But I’ve bought hard into the Matt Ryan hype and happen to believe Atlanta is better than what people are making them out to be. They trust Ryan to make throws in the passing game, can run the ball with Michael Turner and have beaten two quality teams in the Packers and Bears in their last two games. For them to walk away with a win on Sunday, however, the defense will need to step up. Donovan McNabb is shredding opposing defenses and will likely have Brian Westbrook, Reggie Brown and Kevin Curtis back from injuries. But the Falcons have moved the ball well this year, are protecting Ryan (which will be huge this week against Jim Johnson’s blitz-happy defense) and are coming off a bye themselves. They have a lot of momentum after the win over the Bears and have been a more physical team under first-year head coach Mike Smith. A win might be out of reach, but at the very least, I’m calling for a Falcons cover.

Intriguing Matchup: Chargers at Saints, 1:00 PM ET
Both of these teams were highly regarded as playoff contenders in preseason – if not Super Bowl contenders. But both of struggled with inconsistency so far and the Saints will be without Reggie Bush for the next 3 to 4 weeks. LaDainian Tomlinson has not looked like the same MVP back he’s been in recent years, but QB Philip Rivers has more than picked up the slack. Which one of these teams can get back on track this week playing overseas in London? Chances are, the winner might be able to save its season while the loser could start to fall off the playoff radar. (Especially New Orleans, who now plays in a surprisingly tough NFC South.)

Other Notable Games:
Cardinals (4-2) at Panthers (5-2)
Had it not been for the Giants-Steelers game, this matchup might have been the best the NFL had to offer this week. Each team is starting to make some noise, but both have also looked incredibly bad at times this year (see the Cardinals effort against the Jets and the Panthers against the Buccaneers).

Buccaneers (5-2) at Cowboys (4-3), 1:00 PM ET
No Tony Romo again for Dallas – will Monte Kiffin’s defense eat Brad Johnson alive?

Colts (3-3) at Titans (6-0), 8:30 PM ET Monday
The Monday night matchup is a great one. Can Peyton Manning turn around the Colts’ misfortunes this year against the surprising undefeated Titans?