The Texans and Jaguars could be without their biggest offensive weapons on Sunday.

Sources tell ESPN’s Adam Schefter that both Andre Johnson and Maurice Jones-Drew are doubtful for their respective games in Week 16. The Texans are in Denver for a meaningless (in terms of playoffs) game against the Broncos, while the Jaguars play a very meaningful game against the Redskins in Jacksonville.

Johnson told the media earlier in the week that he would test his injured ankle in pre-game warmups but he didn’t sound optimistic that he would play. Should he sit against the Broncos, Jacoby Jones would start in his place and could have a big game against a brutal Denver defense (save for cornerback Champ Bailey, of course).

Jones-Drew’s knee is still swollen and the Jags want to give it a chance to rest and heal. And even though they have a huge game on Sunday, the Redskins’ defense is both decimated and awful, so Jacksonville could probably get by with backup Rashad Jennings if MJD can’t go. Jennings is averaging 6.8 yards-per-carry this season and he should get anywhere from 15-25 touches against Washington.

Here’s a quick Week 16 preview for all of the late games with playoff implications in the NFL this week:

Falcons at Vikings, 4:15PM ET
Who would have thought this game would have so much meaning when the season started? Minnesota needs just one more victory to win the NFC North and put the Chicago Bears out of their misery. They’ll start Tarvaris Jackson again at quarterback this week as Gus Frerotte continues to recovery from a back injury. With a lot of help from Adrian Peterson and the running game, Jackson has been absolutely outstanding since subbing for Frerotte two weeks ago and has thrown five touchdown passes in the last six quarters. The Vikings’ defense took a hit this week when it was discovered that run-stuffer Pat Williams would miss the next 2-6 weeks due to injury. That should help Michael Turner and the Falcons’ dynamic running game stay on track, although they’ll still need a huge contribution from rookie quarterback Matt Ryan, who struggled last week against Tampa. Atlanta needs to win out and hope Dallas or Tampa lose one of their two remaining games. And considering they host the Rams next week, their playoff hopes may reside in beating the Vikings. Can the Falcons’ defense contain Peterson and force Jackson to beat them through the air? Or will the Vikings continue to build momentum as they make a playoff push?

Jets at Seahawks, 4:05PM ET CBS
The Jets are clinging to a slim lead in the AFC East as they currently hold tie-breakers over the Dolphins and Patriots in the division. However, they’re 0-3 on the West Coast this year and a trip to Seattle is never fun for any team come December. This game will also mark Mike Holmgren’s final home game, so you can expect the Seahawks to be ready to play. Still, this is a team the Jets should beat, especially if they consider themselves a legit playoff squad. Seattle’s defense has been brutal this year and as long as Brett Favre can keep from turning the ball over, NY should come up with a big road win.

Bills at Broncos, 4:05PM ET CBS
All the Broncos have to do is win and they clinch the AFC West crown. They won’t have the fortune of facing J.P. Losman, though, as Trent Edwards will resume his starting quarterback duties after missing the past couple weeks due to injury. Denver has been consistently inconsistent this season, especially at home where they currently post a 4-3 record. Buffalo is a disaster, but they did give the Jets a game last week at the Meadowlands and Edwards might (emphasis on might) give the offense a boost. But as long as Denver’s run defense can contain Marshawn Lynch, they should (emphasis on should) be fine.

Eagles at Redskins, 4:15PM ET FOX
The Redskins were officially eliminated from playoff contention last week after an embarrassing loss to the Bengals but you’re crazy if you don’t think they would love to play spoiler. Led by quarterback Donovan McNabb and a stingy defense, the Eagles have played inspired football over the past month and proved two weeks ago in New York that they could win a huge road game. Philly needs to win their final two games to have a shot at a postseason berth and it won’t come easy. After playing in Washington this Sunday, they host the Cowboys next week, who will also be fighting for their playoff lives. If Jim Zorn continues to play things tight to the vest with his play calling, Philly defensive coordinator Jim Johnson might have a field day calling blitzes and confusing quarterback Jason Campbell. But first and foremost, the Eagles have to stop the run or else the passing game will open up and it might allow Zorn to get more creative than he has been of late. Washington’s defense has been solid all year but can anyone slow down McNabb and Brian Westbrook? As long as the Redskins are motivated to ruin the Eagles’ postseason dreams, this should be a great game.

Panthers at Giants, 8:15PM NBC
The battle for the No. 1 seed in the NFC is on the line this week in East Rutherford as the G-Men host the suddenly Super Bowl-caliber Panthers. These are two teams heading in opposite directions as the Giants have lost two straight while Carolina is winners of two in a row. The Panthers have been dominating opponents with their running game over the past two weeks, but they’ll get a huge test this Sunday against a stingy New York front seven. Still, the Giants’ offense has struggled without Plaxico Burress and a healthy Brandon Jacobs, so losing three in a row isn’t out of the question. They need to do a better job of protecting Eli Manning or else the road to the Super Bowl in the NFC will run through Carolina this year. Jacobs is expected to play so that should help, but it remains to be seen how effective he’ll be. And can anyone stop the Panthers’ Steve Smith?

Here’s a quick Week 16 preview for all of the early games with playoff implications in the NFL this week:

Ravens at Cowboys, 8:15PM ET Saturday NFL Network
It’s a shame that only four people will have the opportunity to see this game Saturday night due to the broadcast being on NFL Network. It appears that Marion Barber will play again this week but he doesn’t have a great matchup against a stout Baltimore defense. The Ravens will continue to pound the ball on the ground and keep rookie quarterback Joe Flacco protected, which was one thing the Giants failed to do last week for Eli Manning when they gave up eight sacks in a loss to Dallas. The Cowboys are playing their best defense of the season right now but will all of their off-field issues eventually catch up to them? Can Terrell Owens behave? Will Tony Romo hold this team together?

Steelers at Titans, 1:00PM ET, CBS
Home field advantage in the AFC is on the line in this game, but Tennessee is in trouble. Not only are the Titans coming off a loss, but they also lost DT Albert Haynesworth for the season and managed to score just 12 points on the suddenly hot Houston Texans last Sunday. The Steelers, meanwhile, continue to play the best defense of any team in the NFL and while they still have of a fair amount of issues on the offensive side of the ball, they appear to be the team to beat in the NFL right now. We’ll find out a lot about both teams this Sunday in a game that should be a massive defensive struggle.

Cardinals at Patriots, 1:00PM ET FOX
New England is currently locked in a three-way tie in the AFC East although a win over Arizona would go a long way in earning a division crown because they wrap up the season against the hapless Bills next week. The Cardinals might have won the NFC West two weeks ago, but at 8-6 they don’t look like a team ready for the postseason. They have yet to beat a quality opponent on the road and their defense looked disastrous last week in allowing the Vikings’ Tarvaris Jackson to throw four touchdown passes and Adrian Peterson to do whatever he wanted on the ground. If they hope to get any momentum before the playoffs, the Cards might want to start with a win this Sunday in Foxboro. But that might be tough to do against a Patriots team on a mission.

Chargers at Buccaneers, 1:00PM ET CBS
The Broncos have kept the Chargers in the playoff mix but San Diego’s hopes are hanging by a thread. One more loss or a Denver win and they would officially be eliminated. Tampa Bay is coming off two straight losses to divisional opponents and injuries are mounting along the defensive line. The Buccaneers’ once stout run defense has been gashed for over 450 yards the past two weeks and if LaDainain Tomlinson can get going, the Chargers might be the next opponent to run amuck on Tampa. Still, the Bucs are in good shape for the playoffs if they can muster a win Sunday and they should have a huge advantage this week with wideout Antonio Bryant going against a spotty San Diego secondary. If the Bucs win out, they’ll secure one of the Wild Card seeds in the NFC and after hosting the Chargers this week, they wrap up the season against the Raiders at Raymond James.

The Arizona Cardinals are contemplating sitting wideout Anquan Boldin Sunday against the New England Patriots. Boldin is currently dealing with an injured shoulder.

The injury report did not change from Wednesday except that Early Doucet (hamstring) was back to limited work. Anquan Boldin (shoulder), J.J. Arrington (knee) and DE/LB Travis LaBoy (ankle) didn’t practice and coach Ken Whisenhunt acknowledged that if Arrington and Boldin, in particular, have to sit to be ready for the playoffs, the Cards will do what is most prudent.

This is a no-brainer. If Boldin can’t practice Friday, there’s no sense in having him play on Sunday with the playoffs just weeks away. The Cardinals would surely like to head into the postseason with some momentum (especially after they were just waxed by Minnesota at home last Sunday), but they need to be at full strength or else they don’t stand a chance in the postseason.

Steve Breaston might make a decent option this week for fantasy owners, although New England’s defense has been decent against the pass and the weather won’t be pretty so you might want to find better options.

New Orleans Saints placed running back Reggie Bush on IR Wednesday, effectively ending his season.

Bush injured his left knee against the Carolina Panthers on Oct. 19, and had arthroscopic surgery the next day to repair a torn meniscus. He missed four games for rehabilitation.

He returned to action against Tampa Bay on Nov. 30, but struggled and Coach Sean Payton reduced his playing time because of ineffectiveness.

Bush scored a touchdown against the Atlanta Falcons on Dec. 7 and appeared to be back on track. But he suffered a setback against the Chicago Bears the next week and was benched in the second half, again because of ineffectiveness.

This news obviously elevates Pierre Thomas’s fantasy value ten-fold. Anyone fortunate enough to have him on their roster heading into their championship game this week should feel pretty good about his matchup with the Lions on Sunday.

One has to wonder about the long-term status of Bush in New Orleans. Thomas has been incredibly effective as the workhorse back for the Saints over the second half of the season and is clearly ready to take over Deuce McAllister’s role in Sean Payton’s offense next season. If Bush can’t stay healthy, there’s no way the Saints will re-up once his contract expires. No sense in overpaying for a back that can’t run between the tackles and misses games with various alignments.

John Paulsen and I discussed this topic on our weekly fantasy podcast chat (which will post sometime Thursday morning), so make sure to check it out.

The Minnesota Vikings will have to play their final two games (and possibly all of the postseason) without half of their “Williams wall” after it was determined that Pat Williams will miss 2-6 weeks with a broken right scapula in his shoulder.

The word on Pat Williams is not good for the Vikings.

The Pro Bowl nose tackle has a broken right scapula. Coach Brad Childress said that means Williams will be out from two to six weeks.

The scapula connects the arm bone (humerus) with the collarbone (clavicle), according to extensive internet research.

Williams suffered the injury in the third quarter of yesterday’s win at Arizona. He was playing under a court order that delayed the NFL’s four-game suspension, but now it appears he will at least miss the final two games of the regular season.

Considering Michael Turner the Falcons are coming to town, this isn’t good news for the Vikings. But with the way Jared Allen, Adrian Peterson and Tarvaris Jackson are playing, it might not matter much. Plus, Fred Evans has proved to be a solid backup and the Vikings started getting him more game-time reps when they thought both Williamses would be suspended.