According to Adam Schefter’s Twitter page, Colts defensive end Dwight Freeney is expected to miss 2-3 weeks due to a right quad injury and 49ers.com reports that Frank Gore will miss three weeks with a high right ankle and a right hind foot sprain.

I don’t know if “devastating” is the right word to describe these injuries, but they’re both significant.

The Colts defense has played excellent so far this year, partly because they’ve been able to generate pressure using only their front four. Freeney has been a one-man wrecking crew at times, especially last Sunday night in Arizona. With him out, Indy might not be able to create pressure solely from their front four and it could change the way they game plan.

If rookie Glen Coffee can pick up where he left off in preseason, then the Niners will stay afloat without Gore for a couple weeks. Coffee showed a surprising burst and quickness in preseason and will now have to become a full-time back in just his first year.

What will be interesting to watch unfold is if Coffee can’t be productive. That would put pressure on Shaun Hill to make more plays in the passing game and outside of his play at Minnesota on Sunday and the game-winning drive in Arizona in Week 1 he hasn’t done that.

If San Fran wants to stay atop the NFC West, it’s time for Hill to step up and give the Niners a balanced offensive attack while Gore is out.

When it all boils down to it, football is a pretty easy game. Run the ball effectively, play good defense and don’t turn the ball over.

The Cardinals did none of those things on Sunday night and the Colts cruised to a 31-10 win in Arizona. The Cards rushed for only 24 yards, were shredded by Peyton Manning (24 of 35 for 379 yards, 4 TDs, 1 INT) and turned the ball over three times (twice in the red zone).

Conversely, the Colts rushed for 126 yards (granted, Indy’s passing game set up the run), were relentless generating pressure on Kurt Warner and only turned the ball over once (which didn’t hurt them, because ‘Zona gave the ball right back on their ensuing drive).

You can’t turn the ball over three times and expect to beat a team like the Colts. Arizona hand fed Manning scoring opportunities the entire night and couldn’t catch up. Once the Cards fell behind, their running game was stripped and the front four of the Colts pinned their ears back and harassed Warner. Arizona’s O-line was terrorized by Dwight Freeney and company, which totaled four sacks and 10 QB hits.

Indy looks like an unstoppable force. The offense is still as potent as ever, but the Colts’ defense looks faster, more aggressive and bigger up front. What’s amazing is that Indy’s defense has looked this good despite not having safety Bob Sanders.

The Colts just might be the team to beat again in the AFC.

Last month we started looking at last season’s statistics for position players in fantasy football land, and today we’ll look at a position many often overlook. That’s fantasy defenses, which can sometimes put up just enough points to earn your team a victory once in a while. It’s always smart to try and grab one of the top units, although as we’ve seen before, things change, sometimes drastically, from year to year with fantasy D’s. Me? I like to grab my defense before my kicker. This list is based on point totals from one of my leagues, so keep in mind that stats vary from year to year.

1. Baltimore Ravens—The Ravens’ defense is perennially awesome, and we’ll find out for sure how much of that was due to former coordinator Rex Ryan, who is now the head honcho for the Jets. Ryan took plenty of players with him too, like LB Bart Scott and S Jim Leonhard, but the Ravens still have Ray Lewis, Ed Reed and Terrell Suggs. Reed just keeps getting better every year, and his sick nose for the ball is one reason the Ravens had a league high 26 picks. They will keep scoring low as always, but their 34 sacks last season isn’t much to get excited about. Bottom line: The Ravens won’t be a number one this year, but are still top 10.

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- THE LOVE OF SPORTS ponders what would have happened if the Kentucky Wildcats had defended the in-bounds pass in their crushing Eastern Regional Finals loss to Duke in 1992.

- Deadspin discusses weird Japanese baseball curses.

- TONYBLOGS.NET writes that David Beckham plans to own a MLS team after his career ends. Hopefully this means that High Maintenance Spice will remain in the public eye for a long, long time.

- Calvin Pace (yes, that Calvin Pace) wonders aloud whether or not his linebacker brethren Aaron Curry should be the No. 1 overall pick.