When it all boils down to it, football is a pretty easy game. Run the ball effectively, play good defense and don’t turn the ball over.

The Cardinals did none of those things on Sunday night and the Colts cruised to a 31-10 win in Arizona. The Cards rushed for only 24 yards, were shredded by Peyton Manning (24 of 35 for 379 yards, 4 TDs, 1 INT) and turned the ball over three times (twice in the red zone).

Conversely, the Colts rushed for 126 yards (granted, Indy’s passing game set up the run), were relentless generating pressure on Kurt Warner and only turned the ball over once (which didn’t hurt them, because ‘Zona gave the ball right back on their ensuing drive).

You can’t turn the ball over three times and expect to beat a team like the Colts. Arizona hand fed Manning scoring opportunities the entire night and couldn’t catch up. Once the Cards fell behind, their running game was stripped and the front four of the Colts pinned their ears back and harassed Warner. Arizona’s O-line was terrorized by Dwight Freeney and company, which totaled four sacks and 10 QB hits.

Indy looks like an unstoppable force. The offense is still as potent as ever, but the Colts’ defense looks faster, more aggressive and bigger up front. What’s amazing is that Indy’s defense has looked this good despite not having safety Bob Sanders.

The Colts just might be the team to beat again in the AFC.

Here are quick-hit previews for all the Week 3 games in the NFL.

Redskins (1-1) at Lions (0-2), 1:00PM ET
Don’t be shocked if the Lions end their massive losing streak today at home against a very average Redskins team. Thanks to Jim Zorn’s conservative play calling, Washington’s offense has become unimaginable and bland. If Matthew Stafford limits the turnovers, the Lions have a shot.

Packers (1-1) at Rams (0-2), 1:00PM ET
St. Louis played well defensively last week and Green Bay has major issues along its offensive line – could this be an upset in the making? Probably not. The Rams’ offense has looked atrocious in the first two weeks of the season and although Dom Capers’ defense looked horrendous last week, the Packers should manage to beat a bad St. Louis team. (Although this game might be tighter than most expect.)

49ers (2-0) at Vikings (2-0), 1:00PM ET
This is the only matchup in Week 3 that features two 2-0 teams. This game will be the Vikings’ first real challenge after earning victories against the lowly Browns and Lions in the first two weeks. The key for the 49ers will be stopping Adrian Peterson, because Brett Favre won’t find much success through the air against San Fran’s solid secondary. Can Shaun Hill make enough plays in the passing game to lead his team to victory once the Williams Wall takes away Frank Gore?

Falcons (2-0) at Patriots (1-1), 1:00PM ET
This game will be a great test for both teams to see where they are at this point in the season. A win for the Falcons and they’ll be viewed as one of the elite teams in the NFC, while a loss for the Patriots means that it could be panic time for Tom Brady and Bill Belichick. Conversely, if Atlanta loses then everyone will question whether or not the Falcons can beat the top teams in the league, while a win for New England will quiet some of the concerns surrounding the Pats.

Titans (0-2) at Jets (2-0), 1:00PM ET
A loss for Tennessee would be shocking considering the Titans started 10-0 last year. Rex Ryan and Mark Sanchez have the Jets playing with toughness, emotion and swagger. Will the Titans really fall to 0-3 to star the year? Or will they bring Ryan and Sanchez back down to earth after their hot start has everyone buzzing about the J.E.T.S?

Chiefs (0-2) at Eagles (1-1), 1:00PM ET
Kansas City should be just what the doctor ordered for a Philadelphia team that was absolutely shredded by Drew Brees and the Saints last week. Kevin Kolb will get his second consecutive start filling in for the injured Donovan McNabb, although the Eagles did vow to get Michael Vick on the field in some capacity so keep an eye on that.

Giants (2-0) at Buccaneers (0-2), 1:00PM ET
The Giants have major concerns on the defensive side of the ball due to injuries to Justin Tuck, Kenny Phillips, Aaron Ross and Chris Canty. The Bucs haven’t played well defensively so far this year, but they have moved the ball surprisingly well thanks to Byron Leftwich and Cadillac Williams. Will the G-Men’s injury issues hurt them today in Tampa?

Browns (0-2) at Ravens (2-0), 1:00PM ET
Cleveland is having tons of problems moving the ball offensively, mainly because quarterback Brady Quinn doesn’t look comfortable throwing the ball vertically. Unfortunately for Quinn and the Browns, things don’t get any easier this week when they pay a trip to Baltimore to visit the undefeated Ravens. While Baltimore has issues in its secondary, the Ravens’ offense has had no problem putting points on the board in the first two weeks. The Browns haven’t played that bad defensively, but Joe Flacco and company shouldn’t have any problem securing a win today.

Jaguars (0-2) at Texans (1-1), 1:00PM ET
So who are the real Texans? The ones that were crushed at home in Week 1 by the Jets or the ones that earned a hard-fought win in Tennessee in Week 2? Houston has a perfect chance to show the rest of the league that it can beat up on a bad opponent, because that’s exactly what Jacksonville is. The Jags still have the capability to move the ball offensively, but Jack Del Rio’s defense has major issues that Matt Schaub, Steve Slaton (who is off to a slow start) and Andre Johnson can exploit.

Bears (1-1) at Seahawks (1-1), 4:05PM ET
It’ll be the Seneca Wallace show today in Seattle as he fills in for the injured Matt Hasselbeck (rib). The Hawks have looked like a different team under Wallace then Hasselbeck, so the Bears have a perfect opportunity to earn their second victory of the year. As long as Jay Cutler resembles the quarterback that helped Chicago beat the defending Super Bowl champions last week and not the one that was filthy awful in Green Bay in Week 1, the Bears should be fine.

Saints (2-0) at Bills (1-1), 4:05PM ET
If it weren’t for Leodis McKelvin returning a kickoff instead of taking a knee late in the fourth quarter against the Patriots in Week 1, Buffalo would be 2-0 right now. The Bills will get a huge test today as Drew “MVP” Brees and the Saints’ explosive offense comes to Ralph Wilson Stadium. This is the second week where New Orleans will have to travel to the east coast, although nothing (not even the travel conditions) looks like it can slow the Saints’ offense. New Orleans’ defense is still a question mark, although if the Saints continue to score 40-plus points a game it won’t matter how bad Sean Payton’s squad plays defensively.

Steelers (1-1) at Bengals (1-1), 4:15PM ET
Pittsburgh needs to put its ugly loss to Chicago behind it and pick up a big divisional win in Cincinnati. The Bengals looked great offensively last week in Green Bay and will get the chance to show that they’re going to be competitive this year. Can Carson Palmer move the ball against a stingy Steelers defense?

Broncos (2-0) at Raiders (1-1), 4:15PM ET
It’s amazing to think by the end of the day Josh McDaniels’ Broncos could be 3-0. It’s amazing because this was a team in complete turmoil this offseason and is led by a very limited Kyle Orton. Denver’s defense has been fantastic so far and will face an inconsistent JaMarcus Russell today. Can the Bronco defense continue to play well or is this the week things start to come unglued?

Dolphins (0-2) at Chargers (1-1), 4:15PM ET
This is a matchup of two playoff teams from a year ago that have issues at the start of this season. Miami can run the ball, but their loss to the Colts last Monday night proved that the Dolphins can’t win when they have to throw late. San Diego certainly has all the talent to succeed, but for some reason can’t seem to put it all together. Which team can overcome their weaknesses to earn a much-needed win?

Colts (2-0) at Cardinals (1-1), 8:20PM ET
This will be an interesting test for Peyton Manning and the Colts, because the Cardinals have enough offensive firepower to hang with Indy’s up-tempo offense. Can the Colts continue to win by leaving their defense on the field all game? Will Indy force Kurt Warner to throw the ball vertically instead of relying on short, underneath passes like he did last week? This will be an intriguing game.

Panthers (0-2) at Cowboys (1-1), Monday, 8:30PM ET
A loss would be devastating to the Panthers, who are already two games behind New Orleans and Atlanta in a tough NFC South. A loss for Dallas and the hot seat that Wade Phillips is currently sitting on will be on fire. Likewise for quarterback Tony Romo, who is coming off a brutal performance against the Giants in Week 2. Something has to give for two teams that desperately need a win.

For Week 3 point spreads and over/under totals, click here. For Week 3 picks and predictions, click here.

Along with the odds and over/under totals, here’s a look at some of the marquee matchups for Week 3 in the NFL.

Falcons (2-0) at Patriots (1-1), Sunday, 1:00PM ET
This will be a great test to see where both of these teams currently lie. The Falcons are 2-0 with wins over two struggling 2008 playoff teams, while the Patriots could very easily be 0-2 right now. Behind quarterback Matt Ryan’s (108.5 QB Rating) great start, Atlanta’s offense is gearing up for big things this season, but the defense is giving up 5.1 YPC and just lost starting DT Peria Jerry for the year. New England has its own defensive problems without middle linebacker Jerod Mayo and Tom Brady still hasn’t looked comfortable on his surgically repaired knee. It would be unwise to doubt Bill Belichick and the Patriots, but the Falcons would go a long way in proving that they’re a legitimate Super Bowl contender with a win at Foxboro.
Odds: Patriots –4.

49ers (2-0) at Vikings (2-0), Sunday, 1:00PMET
Who would have thought that the only matchup this week featuring two 2-0 teams would be the 49ers at Vikings? San Francisco’s defense has been solid in the first two games, yielding less than 300 total yards per game and limiting opponents to only 13 PPG. But neither Arizona nor Seattle posed the rushing threat that Adrian Peterson and Minnesota will provide this Sunday. This will be a great test to see where Mike Singletary’s team is and whether or not the Niners are legitimate playoff contenders. Can Shaun Hill beat the Vikings through the air if/when the Williams Wall takes away Frank Gore?
Odds: Vikings –7.

Titans (0-2) at Jets (2-0), Sunday, 1:00PM ET
Panic hasn’t set in yet for Jeff Fisher and the Titans, although a loss this week in East Rutherford would make things unsettling in Tennessee. Jets’ rookie Mark Sanchez has looked more like a five-year pro than a quarterback with only two career starts under his belt, but will this be the week that he finally suffers some growing pains? Tennessee’s defense has a way of making opposing quarterbacks look bad, although that certainly wasn’t the case last week when Houston’s Matt Schaub threw a career high four touchdown passes against the Titans. If Fisher’s squad falls to 0-3, the Titans may never recover. On the flip side, if the Jets start 3-0 they’ll set themselves up for making a run at the AFC East crown.
Odds: Jets –2.5.

(2-0) Colts at Cardinals (1-1), Sunday, 8:20PM ET
If you like watching quick-tempo offenses, then the Sunday night game will be right up your alley. The Colts defeated the Dolphins on Monday might despite only running 35 plays, which means Peyton Manning and the rest of Indy’s offense is already in midseason form. The Cards bounced back from their opening week loss to the 49ers by pounding the Jaguars last Sunday thanks to Kurt Warner’s amazing 24-for-26 passing day. Watching Manning and Warner dissect the opposing defense is going to be one of the more intriguing things to watch in Week 3.
Odds: Cardinals -2.5.

NFL Week 3 Point Spreads and Over/Under Totals:

Titans +2.5 Over 37
Jets –2.5 Under 37

Jaguars +3.5 Over 46.5
Texans –3.5 Under 46.5

Browns +13 Over 38.5
Ravens –13 Under 38.5

Giants –7 Over 44
Bucs +7 Under 44

Redskins –6.5 Over 38.5
Lions +6 Under 38.5

Packers –6.5 Over 41
Rams +6.5 Under 41

49ers +7 Over 40.5
Vikings –7 Under 40.5

Falcons +4 Over 44
Patriots –4 Under 44

Bears –2 Over 37
Seahawks +2 Under 37

Saints –5.5 Over 52.5
Bills +5.5 Under 52.5

Dolphins +6 Over 44
Chargers -6 Under 44

Steelers –4.5 Over 37
Bengals +4.5 Under 37

Broncos +1.5 Over 36
Raiders –1.5 Under 36

Colts +2.5 Over 48
Cardinals -2.5 Under 48

Panthers +9 Over 46
Cowboys –9 Under 46

Check out updated odds on Week 3 at Bullz-Eye.com.