No. 1 Alabama at. No. 19 South Carolina, 3:30PM ET, CBS
After facing Arkansas and Florida the past two weeks, this will be the third top 25 team that the Crimson Tide face in as many weeks. Last season, Mark Ingram rushed for 246 yards against the Gamecocks and Steve Spurrier has lost his only two meetings with ‘Bama since taking over at South Carolina. In fact, the Gamecocks haven’t beaten the Tide since 2004, but they’ll have revenge on their minds this Saturday and will play in the friendly confines of Williams-Brice Stadium.
Current Point Spread: Alabama –6.5 (48)

No. 12 LSU at. No. 14 Florida, 7:30PM ET, ESPN
LSU caught a break last week when Tennessee tried to play with 42 players on defense for the final play of the game. The result was a 16-14 win for the Tigers, who are a very quiet 5-0 right now. Florida suffered its first loss of the season last week against Alabama, who forced four turnovers in a 31-6 rout. The Gators have won 12 straight home games and lead the all-time series between these two teams at 30-23-3.
Current Point Spread: Florida –6.5

No. 23 Florida State at. No. 13 Miami, 8:00OPM ET, ABC
One of college football’s best rivalries renews this Saturday in Miami, where the 3-1 Canes host the 4-1 Seminoles. This will be the first time in four years that both of these teams are ranked and we should see a tight one. The past nine meetings between these two squads were decided by fewer than 10 points, as Miami has won eight of the past 11 games and leads the all-time series 31-23.
Current Point Spread: Miami –6.5

No. 17 Michigan State at. No. 18 Michigan, 3:30PM ET ABC
It’s been roughly 75 years since both these teams were ranked when meeting each other. It’s felt longer than that since either of these squads were relevant, which makes Saturday’s game between these in-state rivals all the more exciting. The Spartans are expected to have head coach Mark Dantonio back, who will return to the field for the first time since suffering a heart attack on September 18. The Spartans have not started 6-0 since 1999 and are looking to beat the Wolverines for the third straight time since 1965 to 1967. Meanwhile, Michigan QB Denard Robinson needs just 95 rushing yards to reach 1,000 on the season and 87 yards to hit the 2,000 mark for total yards.
Current Point Spread: Michigan –4.5

2010 College Football Week 6 Opening Odds & Over/Under Totals:

303 UAB +12.5 Over 49
304 Central Florida -12.5 Under 49

305 Nebraska -11.5 Over 50.5
306 Kansas State +11.5 Under 50.5

307 Connecticut -6 Over 41.5
308 Rutgers +6 Under 41.5

309 Oklahoma State -23.5 Over 62
310 Louisiana-Lafayette +23.5 Under 62

311 Minnesota +22 Over 58
312 Wisconsin -22 Under 58

313 Syracuse +8 Over 44
314 South Florida -8 Under 44

315 Illinois +8 Over 42
316 Penn State -8 Under 42

317 Indiana +22 Over 57.5
318 Ohio State -22 Under 57.5

319 Michigan State +4 Over 64
320 Michigan -4 Under 64

321 Memphis +17 Over 52
322 Louisville -17 Under 52

323 Miami +17 Over 50.5
324 Cincinnati -17 Under 50.5

325 Boston College +9.5 Over 47
326 N.C. State -9.5 Under 47

327 Clemson +3 Over 52
328 North Carolina -3 Under 52

329 Virginia +10 Over 47.5
330 Georgia Tech -10 Under 47.5

331 Temple +3.5 Over 51
332 Northern Illinois -3.5 Under 51

333 Navy -5 Over 48.5
334 Wake Forest +5 Under 48.5

335 UNLV +27.5 Over 49.5
336 West Virginia -27.5 Under 49.5

337 Western Michigan +4.5 Over 50
338 Ball State -4.5 Under 50

339 Tennessee +11.5 Over 48
340 Georgia -11.5 Under 48

341 Eastern Michigan +25.5 Over 53
342 Vanderbilt -25.5 Under 53

343 Utah -6.5 Over 54.5
344 Iowa State +6.5 Under 54.5

345 Colorado +12 Over 52
346 Missouri -12 Under 52

347 Central Michigan +21 Over 53.5
348 Virginia Tech -21 Under 53.5

349 Bowling Green +9.5 Over 52
350 Ohio -9.5 Under 52

351 East Carolina +9.5 Over 59
352 Southern Miss -9.5 Under 59

353 Colorado State +25 Over 48
354 Air Force -25 Under 48

355 Akron +17 Over 47
356 Kent State -17 Under 47

357 Alabama -7 Over 48
358 South Carolina +7 Under 48

359 LSU +7 Over 42.5
360 Florida -7 Under 42.5

361 Wyoming +33.5 Over 50
362 TCU -33.5 Under 50

363 Arizona State +3 Over 62.5
364 Washington -3 Under 62.5

365 UCLA +8 Over 48
366 California -8 Under 48

367 Pittsburgh +6 Over 49.5
368 Notre Dame -6 Under 49.5

369 Army even Over 43
370 Tulane even Under 43

371 Baylor (N) +2.5 Over 62
372 Texas Tech (N) -2.5 Under 62

373 Texas A&M (N) +6 Over 62
374 Arkansas (N) -6 Under 62

375 Florida State +6.5
376 Miami -6.5

377 Utah State +1 Over 53
378 Louisiana Tech -1 Under 53

379 San Jose State +39 Over 61.5
380 Nevada -39 Under 61.5

381 San Diego State -5 Over 50
382 BYU +5 Under 50

383 Oregon -37 Over 70
384 Washington State +37 Under 70

385 Oregon State +7.5 Over 50.5
386 Arizona -7.5 Under 50.5

387 Auburn -6 over 58
388 Kentucky +6 Under 58

389 Purdue +10.5 Over 50.5
390 Northwestern -10.5 Under 50.5

391 Mississippi State -5 Over 56
392 Houston +5 Under 56

393 New Mexico +3.5
394 New Mexico State -3.5

395 USC +9.5 Over 59.5
396 Stanford -9.5 Under 59.5

397 Toledo +39 Over 57.5
398 Boise State -39 Under 575.

399 Tulsa +6 Over 62.5
400 SMU -6 Under 62.5

401 Rice +9.5 Over 57.5
402 UTEP -9.5 Under 57.5

403 Hawaii +11 Over 63.5
404 Fresno State -11 Under 63.5

405 Arkansas State +1
406 North Texas -1

407 Western Kentucky +10 Over 54
408 Florida International -10 Under 54

409 Florida Atlantic +3 Over 48.5
410 Louisiana-Monroe -3 Under 48.5

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Odds makers have released the point spreads for Week 6 in college football. Below are a list of odds for the top 25 and quick-hit previews for every game.

Thursday, October 8
No. 21 Nebraska -3
No. 24 Missouri +3
Both of these teams can light up a scoreboard, but the Huskers have the defensive advantage of the Tigers. Nebraska has the 16th best pass defense in that nation, while MIZZOU has struggled to stop the run this season, allowing opponents to rush for over 130 yards per game.

Saturday, October 10
No. 1 Florida -8
No. 4 LSU +8
The marquee matchup in this week will take place in Baton Rouge, where the Tigers host a banged up Gators team that could be without starting quarterback Tim Tebow (concussion). If Tebow can’t play, Florida will rely on the best defense in the nation to shut down Charles Scott and the LSU offense that has been inconsistent in the first five weeks of the season.

Colorado +32
No. 2 Texas -32
Colt McCoy and company will be fresh coming off a bye and should have any problem scoring against a defense that is allowing 28 points a game.

No. 3 Alabama -6.5
No. 20 Ole Miss +6.5
This matchup lost some luster a couple weeks ago when the Rebels fell in South Carolina, but this will nevertheless be a great test for the Tide’s second best defense. Alabama might be the most complete team in the nation, although Jevan Snead and company are tough to beat at home.

Boston College +13.5
No. 5 Virginia Tech -13.5
Despite all of their injuries, the Eagles have surprised early by compiling a 4-1 record. They upset Wake Forest and Florida State the past two weeks, although Tyrod Taylor and VA Tech pose a unique challenge. It’s never easy to win in Blacksburg, but it’s going to be even tougher this time around for BC as Taylor continues to mature as a passer.

Wisconsin +14
No. 9 Ohio State -14
The Buckeyes have bounced back nicely since their loss to USC and are currently ninth in the nation in total defense. The Badgers have yet to lose and their offense has been potent thanks to running back John Clay, who has been extremely tough to bring down. This is one of the more underrated matchups on the schedule and could decide the winner of the Big Ten.

No. 10 TCU -10
Air Force +10
The Horned Frogs’ aggressive defense continues to give opponents fits, although they’ll get a unique challenge this week against a Falcons team that averages almost 300 yards a game.

Florida A&M N/A
No. 11 Miami N/A
After facing four ranked opponents to start the season, the Canes finally get a break with an easy non-conference foe. That said, this is no time for Jacory Harris and company to take their foot off the pedal with ACC foes Clemson and Wake Forest coming up in a couple of weeks.

Michigan +8
No. 12 Iowa -8
The Hawkeyes have rebounded from their near-embarrassing loss to Northern Iowa at the start of the season and have now built up some moment. While Michigan continues to struggle defensively, Tate Forcier brings another element to the field with his mobility in and out of the pocket. He could have a tough time throwing against the fourth best pass defense in the nation, however.

No. 13 Oregon -6
UCLA +6
Since losing to Boise State in their opener, Oregon has been an unstoppable force, racking up nearly 35 points a game thanks to junior quarterback Jeremiah Masoli’s threat as a runner and a passer. That said, the Bruins have an outstanding secondary and will force the Ducks to beat them with their rushing attack. The team that controls the game on the ground will likely emerge as the winner.

Eastern Illinois N/A
No. 14 Penn State N/A
With non-conference games against Akron, Syracuse, Temple and now Eastern Illinois, it’s clear that Penn State doesn’t want to exert itself too much in the early going.

No. 15 Oklahoma State N/A
Texas A&M N/A
The Cowboys have been flying under the radar since their Week 2 loss to Houston, although wins over Rice and Grambling State won’t turn many heads. They’ll face an Aggie team that was absolutely shredded by Arkansas last week, but one that posses a threat with their offense. It’ll be interesting to see if Jerrod Johnson and A&M can pull off an upset a week after being embarrassed by the Razorbacks.

Iowa State +20
No. 16 Kansas -20
Kansas is another team that has flown under the radar the past couple weeks, although they’ll hardly get a challenge this Saturday. Todd Reesing and company should roll over a Cyclone defense that is allowing over 150 rushing yards per game.

No. 17 Auburn -3
Arkansas +3
The undefeated Tigers finally broke the top 25 with a win over Tennessee last week. Their defense will face a huge challenge this week against a Razorback team that ranks seventh in the nation in passing offense and is coming off a 47-19 beat down of Texas A&M. Can Auburn slow down Ryan Mallett and his trio of receivers?

No. 18 BYU -16.5
UNLV +16.5
The Cougars may be 4-1, but they have issues. Quarterback Max Hall has not played well thus far this season and must cut down on the turnovers. Thanks to running back Harvey Unga, BYU won’t get much of a challenge from UNLV this week, but Hall must step up his game before TCU comes to town in two weeks.

Baylor +25
No. 19 Oklahoma -25
After suffering their second loss of the season, the Sooners won’t make a repeat appearance in the national title game. Sam Bradford might play this week, although there’s a good chance that Bob Stoops will hold him out against Baylor with a trip to Texas coming up next week. The loss season for Oklahoma continues…

No. 22 Georgia Tech +2.5
Florida State -2.5
The Yellow Jackets are averaging over 250 yards per game on the ground this year and would roll over a Seminole defense that is allowing nearly 130 rushing yards per game.

Kentucky +10.5
No. 25 South Carolina -10.5
South Carolina’s defense will prove to be a stiff challenge for Derrick Locke and the Wildcat offense, although the Gamecocks can’t overlook KU with a trip to Alabama coming up next week.